ICD-10-CM diagnosis code
R65.10 Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
- Billable
- Yes, a complete code (FY2026)
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Other codes in R65
4 complete codes in this category.
- R65.10Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction
- R65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction
- R65.20Severe sepsis without septic shock
- R65.21Severe sepsis with septic shock
Documentation tips
- Make sure the note supports every element of the title, “Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction”: each detail in it should be traceable to the history, examination or assessment.
- Code to the highest specificity the documentation supports. If a detail is missing from the note, add it to the note rather than choosing a less specific code by default.
- Check the Tabular List and official guidelines for instructional notes (“code first”, “use additional code”, Excludes1/Excludes2) that apply to R65.
The international WHO ICD-10 also has R65, with its inclusion and exclusion notes; titles and detail can differ from ICD-10-CM.
ICD-10-CM is developed by the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, and is based on the WHO ICD-10. Codes and titles are reproduced unchanged from the FY2026 code list (effective 1 October 2025). Their use here does not imply endorsement by CDC, HHS or the U.S. Government. Changes effective on or after 1 October 2026 may not be reflected yet; check the current release at cdc.gov or cms.gov before submitting claims.
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