R65 is the ICD-10 code for Systemic Inflammatory Response Syndrome [SIRS]. It is a three-character category divided into 5 subcodes; use the subcode whenever the record supports that level of detail. It belongs to the block R50–R69 (General symptoms and signs) in Chapter XVIII, Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified.
- Code type
- Category (3 characters)
- Chapter
- XVIII · R00–R99
- Classification
- WHO ICD-10, 2019 version
Coding notes
- For morbidity, this category should never be used in primary coding. The category is for use in multiple coding to identify this condition resulting from any cause. A code from another chapter should be assigned first to indicate the cause or underlying disease. For mortality, see the instructions in Volume 2.
Subcodes of R65
- R65.0Systemic Inflammatory Response Syndrome of infectious origin without organ failure
- R65.1Systemic Inflammatory Response Syndrome of infectious origin with organ failure
- R65.2Systemic Inflammatory Response Syndrome of non-infectious origin without organ failure
- R65.3Systemic Inflammatory Response Syndrome of non-infectious origin with organ failure
- R65.9Systemic Inflammatory Response Syndrome, unspecified
R65 in national editions
Countries report with their own edition of ICD-10. Most keep the WHO code and add more specific codes beneath it.
R65Systemisches inflammatorisches Response-Syndrom [SIRS]
R65Syndrome de réponse inflammatoire systémique [SRIS]
R65systemisch inflammatoir-responssyndroom
Based on the World Health Organization’s International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10), 2019 version, and the national editions published by each country’s health authority. This page is a reference, not coding advice; follow your national coding rules when you report.
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