ICD-10-CM diagnosis code
C81.27 Mixed cellularity Hodgkin lymphoma, spleen
- Billable
- Yes, a complete code (FY2026)
- Category
- C81 Hodgkin lymphoma
- Chapter
- 2. Neoplasms
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Other codes in C81
77 complete codes in this category.
- C81.21Mixed cellularity Hodgkin lymphoma, lymph nodes of head, face, and neck
- C81.22Mixed cellularity Hodgkin lymphoma, intrathoracic lymph nodes
- C81.23Mixed cellularity Hodgkin lymphoma, intra-abdominal lymph nodes
- C81.24Mixed cellularity Hodgkin lymphoma, lymph nodes of axilla and upper limb
- C81.25Mixed cellularity Hodgkin lymphoma, lymph nodes of inguinal region and lower limb
- C81.26Mixed cellularity Hodgkin lymphoma, intrapelvic lymph nodes
- C81.27Mixed cellularity Hodgkin lymphoma, spleen
- C81.28Mixed cellularity Hodgkin lymphoma, lymph nodes of multiple sites
- C81.29Mixed cellularity Hodgkin lymphoma, extranodal and solid organ sites
- C81.2AMixed cellularity Hodgkin lymphoma, in remission
- C81.30Lymphocyte depleted Hodgkin lymphoma, unspecified site
- C81.31Lymphocyte depleted Hodgkin lymphoma, lymph nodes of head, face, and neck
Documentation tips
- Make sure the note supports every element of the title, “Mixed cellularity Hodgkin lymphoma, spleen”: each detail in it should be traceable to the history, examination or assessment.
- Code to the highest specificity the documentation supports. If a detail is missing from the note, add it to the note rather than choosing a less specific code by default.
- Check the Tabular List and official guidelines for instructional notes (“code first”, “use additional code”, Excludes1/Excludes2) that apply to C81.
The international WHO ICD-10 also has C81, with its inclusion and exclusion notes; titles and detail can differ from ICD-10-CM.
ICD-10-CM is developed by the National Center for Health Statistics (NCHS), Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, and is based on the WHO ICD-10. Codes and titles are reproduced unchanged from the FY2026 code list (effective 1 October 2025). Their use here does not imply endorsement by CDC, HHS or the U.S. Government. Changes effective on or after 1 October 2026 may not be reflected yet; check the current release at cdc.gov or cms.gov before submitting claims.
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